Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

551476
Purchase on Sigma-Aldrich

Panoramica

Tabella delle specifiche principali

Empirical Formula
C₂₆H₂₅F₂N₃O₆

Products

Numero di catalogoConfezionamento Qtà/conf
551476-1MG Fiala di plastica 1 mg
551476-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Catalogue Number551476
Brand Family Calbiochem®
SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
References
ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
Caserta, T.M., et al. 2003. Apoptosis 8, 345.
Rebbaa, A., et al. 2003. Oncogene 22, 2805.
Product Information
ATP CompetitiveN
FormLiquid
FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Hill FormulaC₂₆H₂₅F₂N₃O₆
Chemical formulaC₂₆H₂₅F₂N₃O₆
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetcaspase-1
Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceQ-Val-Asp-CH₂-OPh
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
551476-1MG 04055977268898
551476-5MG 04055977268904