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500582 InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA

Primary Target: PKC
500582
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
16561-29-8C₃₆H₅₆O₈

Products

Numero di catalogoConfezionamento Qtà/conf
5005820001 Bottiglia di vetro 2 mg
Description
OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
Catalogue Number500582
Brand Family Calbiochem®
Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
References
ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
Perchellet, J. 1985. Carcinogenesis 6, 567.
Nishizuka, Y. 1984. Science 255, 1365.
Mastro, A. 1982. Lymphokines 6, 263.
Product Information
CAS number16561-29-8
FormLiquid
FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
Hill FormulaC₃₆H₅₆O₈
Chemical formulaC₃₆H₅₆O₈
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Secondary targetCa2+-ATPase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
5005820001 04055977244977

Documentation

InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Riferimenti bibliografici

Panoramica delle referenze
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
Perchellet, J. 1985. Carcinogenesis 6, 567.
Nishizuka, Y. 1984. Science 255, 1365.
Mastro, A. 1982. Lymphokines 6, 263.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2013 JSW
Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
DescriptionMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
FormLiquid
FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number16561-29-8
Chemical formulaC₃₆H₅₆O₈
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
Toxicity Irritant
ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
Perchellet, J. 1985. Carcinogenesis 6, 567.
Nishizuka, Y. 1984. Science 255, 1365.
Mastro, A. 1982. Lymphokines 6, 263.