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528151 InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem

The InSolution™ PARP Inhibitor VIII, PJ34 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl

Primary Target: PARP
528151
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
344458-19-1C₁₇H₁₇N₃O₂ • HCl

Products

Numero di catalogoConfezionamento Qtà/conf
528151-2MG Bottiglia di vetro 2 mg
Description
OverviewA water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528151) is also available.
Catalogue Number528151
Brand Family Calbiochem®
Synonyms2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl
References
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
Product Information
CAS number344458-19-1
FormLiquid
FormulationA 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.
Hill FormulaC₁₇H₁₇N₃O₂ • HCl
Chemical formulaC₁₇H₁₇N₃O₂ • HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPARP
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Harmful
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
528151-2MG 04055977196429

Documentation

InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
528151

Riferimenti bibliografici

Panoramica delle referenze
Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-December-2012 JSW
Synonyms2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl
DescriptionA water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150) is also available.
FormLiquid
FormulationA 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number344458-19-1
Chemical formulaC₁₇H₁₇N₃O₂ • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Harmful
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.