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487929 InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.

InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate

Primary Target: Microtubules
487929
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Tabella delle specifiche principali

CAS #Empirical Formula
31430-18-9C₁₄H₁₁N₃O₃S

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Numero di catalogoConfezionamento Qtà/conf
487929-10MG Bottiglia di vetro 10 mg
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Description
OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
Catalogue Number487929
Brand Family Calbiochem®
SynonymsR17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate
References
ReferencesPark, H., et al. 2012. Chem. Med. Chem. 7, 53.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
Product Information
CAS number31430-18-9
FormLiquid
FormulationA 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
Hill FormulaC₁₄H₁₁N₃O₃S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMicrotubules
Secondary targetCertain kinases
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
487929-10MG 04055977200393