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422712 InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem

InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: cam kinase 2
422712
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
139298-40-1C₂₆H₂₉ClN₂O₄S

Products

Numero di catalogoConfezionamento Qtà/conf
422712-1MG Fiala di plastica 1 mg
Description
Catalogue Number422712
Brand Family Calbiochem®
References
ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Product Information
CAS number139298-40-1
ATP CompetitiveN
FormLiquid
FormulationA 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
Hill FormulaC₂₆H₂₉ClN₂O₄S
Chemical formulaC₂₆H₂₉ClN₂O₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcam kinase 2
Primary Target K<sub>i</sub>370 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
422712-1MG 04055977187281

Documentation

InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
422712

Riferimenti bibliografici

Panoramica delle referenze
Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-January-2023 JSW
DescriptionA cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
FormLiquid
FormulationA 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number139298-40-1
Chemical formulaC₂₆H₂₉ClN₂O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.