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124015 InSolution™ Akt Inhibitor IV - Calbiochem

The InSolution™ Akt Inhibitor IV controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Akt Inhibitor IV - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: Akt
124015
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₃₁H₂₇IN₄S

Products

Numero di catalogoConfezionamento Qtà/conf
124015-1MG Fiala di plastica 1 mg
Description
Catalogue Number124015
Brand Family Calbiochem®
References
ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
Hill FormulaC₃₁H₂₇IN₄S
Chemical formulaC₃₁H₂₇IN₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells
Purity≥98% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
124015-1MG 07790788047986

Documentation

InSolution™ Akt Inhibitor IV - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

InSolution™ Akt Inhibitor IV - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
124015

Riferimenti bibliografici

Panoramica delle referenze
Kau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Brochure

Titolo
Akt
Biologics 31.1
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-April-2008 RFH
DescriptionA cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 < 1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.
FormLiquid
FormulationA 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₃₁H₂₇IN₄S
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.