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382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator

382120
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
451491-47-7C₁₆H₁₃ClF₃NO₂

Products

Numero di catalogoConfezionamento Qtà/conf
382120-25MG Fiala di plastica 25 mg
Description
OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
Catalogue Number382120
Brand Family Calbiochem®
SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
References
ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
Product Information
CAS number451491-47-7
FormOff-white solid
Hill FormulaC₁₆H₁₃ClF₃NO₂
Chemical formulaC₁₆H₁₃ClF₃NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
382120-25MG 04055977213133

Documentation

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
382120

Riferimenti bibliografici

Panoramica delle referenze
Mantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-September-2017 JSW
SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
DescriptionA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number451491-47-7
Chemical formulaC₁₆H₁₃ClF₃NO₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityEthanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.