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373260 Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I

Primary Target: Hsp70
373260
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
218924-25-5C₁₃H₁₁NO₄

Products

Numero di catalogoConfezionamento Qtà/conf
373260-5MG Bottiglia di vetro 5 mg
Description
OverviewA benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.
Catalogue Number373260
Brand Family Calbiochem®
SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
References
ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
Yokota, S., et al. 2000. Cancer Res. 60, 2942.
Product Information
CAS number218924-25-5
ATP CompetitiveN
FormWhite to light yellow powder
Hill FormulaC₁₃H₁₁NO₄
Chemical formulaC₁₃H₁₁NO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHsp70
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
373260-5MG 04055977191004

Documentation

Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
373260

Riferimenti bibliografici

Panoramica delle referenze
Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
Yokota, S., et al. 2000. Cancer Res. 60, 2942.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
DescriptionA benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
FormWhite to light yellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number218924-25-5
Chemical formulaC₁₃H₁₁NO₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (3 mg/ml) or Olive oil
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity Harmful
ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
Yokota, S., et al. 2000. Cancer Res. 60, 2942.