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368055 Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Caspase-8 Inhibitor I, Ac-IETD-CHO

Primary Target: caspase-8
368055
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1258003-96-1C₂₁H₃₄N₄O₁₀

Products

Numero di catalogoConfezionamento Qtà/conf
368055-1MG Fiala di plastica 1 mg
Description
OverviewA potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Catalogue Number368055
Brand Family Calbiochem®
SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
References
ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
Product Information
CAS number1258003-96-1
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₁H₃₄N₄O₁₀
Chemical formulaC₂₁H₃₄N₄O₁₀
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-8
Primary Target K<sub>i</sub>1 nM against caspase-8
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
368055-1MG 04055977192131

Documentation

Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
368055

Riferimenti bibliografici

Panoramica delle referenze
Gao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Brochure

Titolo
Caspases and other Apoptosis Related Tools Brochure
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
DescriptionPotent, reversible granzyme B and caspase-8 inhibitor.
FormWhite lyophilized solid
CAS number1258003-96-1
Chemical formulaC₂₁H₃₄N₄O₁₀
Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.