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361546 GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: L803-mts, Myr-N-GKEAPPAPPQSpP-NH₂

Primary Target: Gsk-3β
361546
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₆₆H₁₁₀N₁₅O₂₀P

Products

Numero di catalogoConfezionamento Qtà/conf
361546-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displays in vivo stability.
Catalogue Number361546
Brand Family Calbiochem®
SynonymsL803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
References
ReferencesPlotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.
Product Information
ATP CompetitiveN
DeclarationThis product is covered by one or more US patents and/or patent applications and foreign counter-parts owned by Tel Aviv University Future Technology LP, a limited partnership formed under the laws of Israel. Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey the right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR USE IN HUMANS. For information on purchasing a license to this product for purposes other than research, contact VP Business Development, Ramot at Tel Aviv University Ltd., Tel Aviv University, Licensor-Aviv, Tel Aviv 61392, Israel, Phone: +972 3 640 6608; Fax: +972 3 640 6675.
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₆H₁₁₀N₁₅O₂₀P
Chemical formulaC₆₆H₁₁₀N₁₅O₂₀P
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetGsk-3β
Primary Target IC<sub>50</sub>40 µM against Gsk-3β
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceMyr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
361546-1MG 04055977214024

Documentation

GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
361546

Riferimenti bibliografici

Panoramica delle referenze
Plotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.

Brochure

Titolo
Alzheimer's Disease Brochure & Technical Guide
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-July-2008 RFH
SynonymsL803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
DescriptionA cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc-2, PKB, or PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~ 2.5-fold) in HEK293 cells. Also reported to improve glucose tolerance in diabetic mice. Exhibits greater in vivo stability.
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₆H₁₁₀N₁₅O₂₀P
Peptide SequenceMyr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml) or CH₃CN:H₂O (1:1) (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesPlotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.