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341608 FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea

341608
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
192705-79-6C₂₀H₂₄N₆O₃

Products

Numero di catalogoConfezionamento Qtà/conf
341608-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
Catalogue Number341608
Brand Family Calbiochem®
SynonymsPD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
References
ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
Product Information
CAS number192705-79-6
FormOff-white solid
Hill FormulaC₂₀H₂₄N₆O₃
Chemical formulaC₂₀H₂₄N₆O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
341608-5MG 04055977195217

Documentation

FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
341608

Riferimenti bibliografici

Panoramica delle referenze
Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
SynonymsPD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
DescriptionA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number192705-79-6
Chemical formulaC₂₀H₂₄N₆O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.