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434741 ETYA - CAS 1191-85-1 - Calbiochem

Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.

ETYA - CAS 1191-85-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 5,8,11,14-Eicosatetraynoic Acid

Primary Target: PLA₂
434741
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1191-85-1C₂₀H₂₄O₂

Products

Numero di catalogoConfezionamento Qtà/conf
434741-20MG Fiala di plastica 20 mg
Description
OverviewCell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. Also acts as a potent modulator of Ca2+ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
Catalogue Number434741
Brand Family Calbiochem®
Synonyms5,8,11,14-Eicosatetraynoic Acid
References
ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
Product Information
CAS number1191-85-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₄O₂
Chemical formulaC₂₀H₂₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPLA₂
Primary Target IC<sub>50</sub>8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
434741-20MG 04055977210286

Documentation

ETYA - CAS 1191-85-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

ETYA - CAS 1191-85-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
434741

Riferimenti bibliografici

Panoramica delle referenze
Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-August-2008 RFH
Synonyms5,8,11,14-Eicosatetraynoic Acid
DescriptionCell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. A potent modulator of Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.
FormOff-white solid
CAS number1191-85-1
Chemical formulaC₂₀H₂₄O₂
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO or Ethanol (20 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.