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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
324890
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
66701-25-5C₁₅H₂₇N₅O₅

Products

Numero di catalogoConfezionamento Qtà/conf
324890-1MG Fiala di plastica 1 mg
324890-25MG Bottiglia di vetro 25 mg
324890-5MG Fiala di plastica 5 mg
Description
OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
Catalogue Number324890
Brand Family Calbiochem®
Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
References
ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.
Product Information
CAS number66701-25-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₇N₅O₅
Chemical formulaC₁₅H₂₇N₅O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
Biological Information
Primary Targetcysteine proteases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRR0390000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
324890-1MG 04055977196146
324890-25MG 04055977196160
324890-5MG 04055977196177

Documentation

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
324890

Riferimenti bibliografici

Panoramica delle referenze
Matsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.

Citazioni

Titolo
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-July-2013 JSW
    Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
    DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
    FormWhite solid
    CAS number66701-25-5
    RTECSRR0390000
    Chemical formulaC₁₅H₂₇N₅O₅
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
    Sarin, A., et al. 1994. J. Immunol. 153, 862.
    Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
    Barrett, A.J. 1982. Biochem. J. 201, 189.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•