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260920 DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I

Primary Target: CPG methylase M.Sssl
260920
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
32675-71-1C₁₉H₁₄N₂O₄

Products

Numero di catalogoConfezionamento Qtà/conf
260920-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
Catalogue Number260920
Brand Family Calbiochem®
Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
References
ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.
Product Information
CAS number32675-71-1
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₉H₁₄N₂O₄
Chemical formulaC₁₉H₁₄N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCPG methylase M.Sssl
Primary Target IC<sub>50</sub>115 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
260920-10MG 04055977217520

Documentation

DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
260920

Riferimenti bibliografici

Panoramica delle referenze
Brueckner, B., et al. 2005. Cancer Res. 65, 6305.

Informazioni tecniche

Titolo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
DescriptionA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number32675-71-1
Chemical formulaC₁₉H₁₄N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.