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217694 Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

217694
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
93718-83-3C₁₄H₁₄O₄S₂

Products

Numero di catalogoConfezionamento Qtà/conf
217694-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Catalogue Number217694
Brand Family Calbiochem®
Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
References
ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
Product Information
CAS number93718-83-3
FormOrange solid
Hill FormulaC₁₄H₁₄O₄S₂
Chemical formulaC₁₄H₁₄O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
217694-10MG 04055977202304

Documentation

Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
217694

Riferimenti bibliografici

Panoramica delle referenze
Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
DescriptionA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number93718-83-3
Chemical formulaC₁₄H₁₄O₄S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml; clear red solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.