Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

219373 Cathepsin G, Human Neutrophil

Cathepsin G, Human Neutrophil, CAS 107200-92-0, is a purified native cathepsin G. Acts as a potent agonist of human platelet activation leading to their aggregation.

Cathepsin G, Human Neutrophil: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
219373
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
219373-100MIU Fiala di plastica 100 miu
Description
OverviewNative cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Reported to be involved in the activation of pro MMP-2 via mechanism requiring MT1-MMP. Inhibited by chymostatin, DFP, and Z-Phe-CH2Br. Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
Note: 1 mU = 1 milliunit.
Catalogue Number219373
Brand Family Calbiochem®
References
ReferencesGlusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
Maison, C.M., et al. 1991. J. Immunol. 147, 921.
Travis, J. 1988. Am. J. Med. 84, 37.
Product Information
CAS number107200-92-0
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-<i>p</i>NA per min at 25°C, pH 7.5.
EC number3.4.21.20
FormSalt-free lyophilized solid
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥2 units/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
219373-100MIU 04055977201574

Documentation

Cathepsin G, Human Neutrophil MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cathepsin G, Human Neutrophil Certificati d'Analisi

TitoloNumero di lotto
219373

Riferimenti bibliografici

Panoramica delle referenze
Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
Maison, C.M., et al. 1991. J. Immunol. 147, 921.
Travis, J. 1988. Am. J. Med. 84, 37.

Brochure

Titolo
Cathepsins and Related Products Technical Bulletin

Citazioni

Titolo
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-April-2008 RFH
    DescriptionNative cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases, such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Inhibited by chymostatins, DFP and Z-Phe-CH2Br.
    FormSalt-free lyophilized solid
    SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
    CAS number107200-92-0
    EC number3.4.21.20
    Purity≥95% by SDS-PAGE
    Specific activity≥2 units/mg protein
    Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5.
    SolubilityReconstitute in 50 mM NaOAc and 150 mM NaCl, pH 5.5.
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
    Toxicity Standard Handling
    Merck USA index14, 1905
    ReferencesGlusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
    Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
    Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
    Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
    Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
    Maison, C.M., et al. 1991. J. Immunol. 147, 921.
    Travis, J. 1988. Am. J. Med. 84, 37.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
    		•