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219385 Cathepsin B Inhibitor II - Calbiochem

The Cathepsin B Inhibitor II controls the biological activity of Cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Cathepsin B Inhibitor II - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Ac-LVK-CHO

Primary Target: cathepsin B
219385
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₉H₃₆N₄O₄

Products

Numero di catalogoConfezionamento Qtà/conf
219385-1MG Fiala di plastica 1 mg
Description
OverviewA more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) compared to leupeptin (IC50 = 310 nM).
Note: this peptide forms cyclic isomers.
Catalogue Number219385
Brand Family Calbiochem®
SynonymsAc-LVK-CHO
References
ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₆N₄O₄
Chemical formulaC₁₉H₃₆N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>4 nM against cathepsin B
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Leu-Val-lysinal
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
219385-1MG 04055977201666

Documentation

Cathepsin B Inhibitor II - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cathepsin B Inhibitor II - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
219385

Riferimenti bibliografici

Panoramica delle referenze
McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

Brochure

Titolo
Cathepsins and Related Products Technical Bulletin

Citazioni

Titolo
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-October-2007 RFH
    SynonymsAc-LVK-CHO
    DescriptionLysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) than of leupeptin (IC50 = 310 nM). Note: this peptide forms cyclic isomers.
    FormWhite solid
    Chemical formulaC₁₉H₃₆N₄O₄
    Peptide SequenceAc-Leu-Val-lysinal
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityH₂O (1 mg/ml)
    Storage ≤ -70°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
    Toxicity Standard Handling
    ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
    Citation
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    		•