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208724 Calpain Inhibitor IV - Calbiochem

Calpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).

Calpain Inhibitor IV - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Z-LLY-FMK

Primary Target: calpain 2
208724
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₃₀H₄₀FN₃O₆

Products

Numero di catalogoConfezionamento Qtà/conf
208724-1MG Fiala di plastica 1 mg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
Catalogue Number208724
Brand Family Calbiochem®
SynonymsZ-LLY-FMK
References
ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
Product Information
ATP CompetitiveN
FormWhite to pale yellow solid
Hill FormulaC₃₀H₄₀FN₃O₆
Chemical formulaC₃₀H₄₀FN₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).
Biological Information
Primary Targetcalpain 2
Primary Target IC<sub>50</sub>k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
Puritysingle spot by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
208724-1MG 04055977202694

Documentation

Calpain Inhibitor IV - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Calpain Inhibitor IV - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
208724

Riferimenti bibliografici

Panoramica delle referenze
Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Brochure

Titolo
Caspases and other Apoptosis Related Tools Brochure

Citazioni

Titolo
  • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-May-2013 JSW
    SynonymsZ-LLY-FMK
    DescriptionA potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
    FormWhite to pale yellow solid
    Chemical formulaC₃₀H₄₀FN₃O₆
    Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
    Structure formulaStructure formula
    Puritysingle spot by TLC
    SolubilityDMSO (25 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
    Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
    Citation
  • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
    		•