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208921 Calmodulin Kinase IINtide, Myristoylated - Calbiochem

The myristoylated form of CaMK IINtide.

Calmodulin Kinase IINtide, Myristoylated - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Myr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH

Primary Target: Calmodulin-Dependent Protein Kinase (CaM Kinase)-2
208921
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₅₆H₂₇₅N₄₇O₄₃

Products

Numero di catalogoConfezionamento Qtà/conf
208921-1MG Fiala di plastica 1 mg
Description
OverviewThe myristoylated form of CaMK IINtide (Cat. No. 208920). The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
Catalogue Number208921
Brand Family Calbiochem®
SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
References
ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Product Information
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₅₆H₂₇₅N₄₇O₄₃
Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase)-2
Primary Target IC<sub>50</sub>50 nM against cam Kinase-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
208921-1MG 04055977219555

Documentation

Calmodulin Kinase IINtide, Myristoylated - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Calmodulin Kinase IINtide, Myristoylated - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
208921

Riferimenti bibliografici

Panoramica delle referenze
Sodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
DescriptionThe myristoylated form of CaMK IINtide (Cat. No. 208920), a potent, specific inhibitor of Ca2+/Calmodulin kinase II (CaMK II) (IC50 = 50 nM for total and Ca2+-independent CaMK II activity). The peptide sequence corresponds to the inhibitory domain of the CaMK II inhibitory protein, CaMK IIN. Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 = 100-400 nM). Shown to completely inhibit the phosphorylation of GluR1 fusion protein at a concentration of 1 µM. Does not inhibit CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
Toxicity Standard Handling
ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.