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208293 Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - CAS 407587-33-1 - Calbiochem

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - CAS 407587-33-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I

208293
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
407587-33-1C₁₈H₂₁NO₄S

Products

Numero di catalogoConfezionamento Qtà/conf
208293-10MG Bottiglia di vetro 10 mg
Description
OverviewAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).
Catalogue Number208293
Brand Family Calbiochem®
SynonymsTMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
References
ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
Product Information
CAS number407587-33-1
FormOff-white solid
Hill FormulaC₁₈H₂₁NO₄S
Chemical formulaC₁₈H₂₁NO₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
208293-10MG 04055977203264

Documentation

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - CAS 407587-33-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - CAS 407587-33-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
208293

Riferimenti bibliografici

Panoramica delle referenze
Fuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2012 JSW
SynonymsTMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
DescriptionAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number407587-33-1
Chemical formulaC₁₈H₂₁NO₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; pale yellow solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.