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SCC041 C20A4 Human Chondrocyte Cell Line

C20A4 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.

C20A4 Human Chondrocyte Cell Line: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Key Applications: Cell Culture
SCC041
≥1X10⁶ cells/vial  
Purchase on Sigma-Aldrich

Offerte speciali

Panoramica

Replacement Information

Offerte speciali

Explore additional Chondrocyte cell lines:
TC28a2 Human Chondrocyte Cell Line (Catalogue Number SCC042)
C28/I2 Human Chondrocyte Cell Line (Catalogue Number SCC043)

Tabella delle specifiche principali

Key Applications
CULT
Description
Catalogue NumberSCC041
DescriptionC20A4 Human Chondrocyte Cell Line
OverviewThe chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. Studies on human chondrocytes have been hampered by the difficulty in obtaining sufficient numbers of primary human chondrocytes from a single joint and by variabilities among donors due to factors such as age and medical conditions.

C-20/A4 cell line was established by transfecting primary cultures of rib chondrocytes from a 5-year-old male with vectors expressing origin-defective simian virus SV40 large T antigen.

References:
1. Goldring, M.B, Birkhead, J.R., Suen, L.F., Yamin, R., Mizuno, S., Glowacki, J., Arbiser, J.L, Apperley, J.F. (1994) Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest 94(6): 2307-2316.
2. Finger, F., Schorle, C., Soder, S., Zien, A., Goldring, M.B., Aigner, T. (2004) Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture. Cells Tissues Organs. 178(2): 65-77.
3. Goldring, M.B. (2004) Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods Mol. Med. 100: 37-52.
Alternate Names
  • C-20/A4
    C20/A4
References
Product Information
HS Code3002 90 99
Quality LevelMQ100
Applications
ApplicationC20A4 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.
Key Applications
  • Cell Culture
Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Biological Information
ConcentrationPlease refer to lot specific datasheet.
Cell Line Type
  • Chondrocyte Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
Usage Statement
  • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥1X10⁶ cells/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
SCC041 04054839090974