Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

189497 Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

189497
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
315702-99-9C₁₅H₁₃N₃S

Products

Numero di catalogoConfezionamento Qtà/conf
189497-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
Catalogue Number189497
Brand Family Calbiochem®
SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
References
ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.
Product Information
CAS number315702-99-9
FormBeige solid
Hill FormulaC₁₅H₁₃N₃S
Chemical formulaC₁₅H₁₃N₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-41

Harmful if swallowed.
Risk of serious damage to eyes.
S PhraseS: 26-39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
189497-10MG 04055977221855

Documentation

Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
189497

Riferimenti bibliografici

Panoramica delle referenze
Turcotte, S., et al. 2008. Cancer Cell 14, 90.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-August-2009 RFH
SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
DescriptionA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number315702-99-9
Chemical formulaC₁₅H₁₃N₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.