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178276 Apicidin, Fusarium sp. - Calbiochem

A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties.

Apicidin, Fusarium sp. - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

Primary Target: Histone deacetylase
178276
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₃₄H₄₉N₅O₆

Products

Numero di catalogoConfezionamento Qtà/conf
178276-1MG Fusto in alluminio 1 mg
178276-5MG Fusto in alluminio 5 mg
Description
OverviewA potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
Catalogue Number178276
Brand Family Calbiochem®
Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
References
ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₄H₄₉N₅O₆
Chemical formulaC₃₄H₄₉N₅O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHistone deacetylase
Primary Target IC<sub>50</sub>700 pM for parasitic histone deactetylase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
178276-1MG 04055977222401
178276-5MG 04055977222418

Documentation

Apicidin, Fusarium sp. - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Apicidin, Fusarium sp. - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
178276

Riferimenti bibliografici

Panoramica delle referenze
Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

Informazioni tecniche

Titolo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-February-2019 JSW
Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
DescriptionA potent, cell-permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₄H₄₉N₅O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Highly Toxic
ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.