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07-1352 Anti-acetyl STAT5B (Lys701) Antibody

Detect acetyl STAT5B (Lys701) using this Anti-acetyl STAT5B (Lys701) Antibody validated for use in DB & WB.

Anti-acetyl STAT5B (Lys701) Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: STAT5B UniProt Number: P51692
07-1352
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HDB, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number07-1352
DescriptionAnti-acetyl STAT5B (Lys701) Antibody
Alternate Names
  • Signal transducer and activator of transcription 5B
Background InformationSTAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors.
References
Product Information
FormatAffinity Purified
Control
  • Modified and non modified peptides of acetylated and non-acetylated STAT5B protein
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect acetyl STAT5B (Lys701) using this Anti-acetyl STAT5B (Lys701) Antibody validated for use in DB & WB.
Key Applications
  • Dot Blot
  • Western Blotting
Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.)
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human STAT5B acetylated at Lys701.
EpitopeAcetylated Lys701
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes STAT5B acetylated at Lys701.
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with Human. Other homologies: Rat and Mouse (91% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • STAT5B
Modifications
  • Acetylation
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.

SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Translocated into the nucleus in response to phosphorylation (By similarity).

INVOLVEMENT IN DISEASE: Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.

SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.
Molecular Weight90 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.

Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
07-1352 04053252520709