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ABF292 Anti-ZC3H12A Antibody

Anti-ZC3H12A Antibody detects level of ZC3H12A & has been published & validated for use in ZC3H12A.

Anti-ZC3H12A Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: ZC3H12A, MCPIP, MCPIP1 UniProt Number: Q5D1E8
ABF292
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF292
DescriptionAnti-ZC3H12A Antibody
Alternate Names
  • Ribonuclease ZC3H12A
  • MCP-induced protein 1
  • Zinc finger CCCH domain-containing protein 12A
Background InformationRibonuclease ZC3H12A, also known as MCP-induced protein 1 or Zinc finger CCCH domain-containing protein 12A, and encoded by the gene name ZC3H12A or MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation. ZC3H12A may be involved in host immunity and inflammatory diseases. It has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPγ.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-ZC3H12A Antibody detects level of ZC3H12A & has been published & validated for use in ZC3H12A.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human ZC3H12A.
Epitopecenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • ZC3H12A
  • MCPIP
  • MCPIP1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Raji Cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ZC3H12A in Raji Cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABF292 04053252945229