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MAB2613 Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12

Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH.

Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Cell Structure Gene Symbol: MRC2, CD280, CLEC13E, ENDO180, UPARAP UniProt Number: Q9UBG0
MAB2613
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB2613
DescriptionAnti-UPAR-Associated Protein Antibody, clone 2.h.9:F12
Alternate Names
  • CD280
  • Endocytic receptor 180
  • Macrophage mannose receptor 2
  • UPAR-associated protein
  • Urokinase receptor-associated protein
  • Endocytic receptor 180
  • C-type mannose receptor 2
Background InformationUrokinase plasminogen activator receptor-associated protein (uPARAP/Endo180/MRC2) is a member of the macrophage mannose receptor family of endocytic transmembrane glycoproteins. UPAR-Associated Protein is a membrane protein involved in matrix turnover during tissue remodeling, particularly the uptake and intracellular degradation of collagen, (Sulek, 2007).
Product Information
FormatPurified
Control
  • U937 cell lysate
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
ImmunogenuPAR D3-tagged recombinant protein corresponding to human UPAR-Associated Protein.
EpitopeUnknown
Clone2.h.9:F12
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThe antibody recognizes UPAR-Associated Protein.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryMRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM].
Gene Symbol
  • MRC2
  • CD280
  • CLEC13E
  • ENDO180
  • UPARAP
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

SUBUNIT STRUCTURE: Interacts with C-terminal region of type I collagen/COL1A1 By similarity. Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

DOMAIN: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.

Fibronectin type-II domain mediates collagen-binding.

Ricin B-type lectin domain contacts with the second C-type lectin domain By similarity.

PTM: Phosphorylated.

N-glycosylated.

SEQUENCE SIMILARITIES: Contains 8 C-type lectin domains.

Contains 1 fibronectin type-II domain.

Contains 1 ricin B-type lectin domain.
Molecular Weight ~ 180 kDa
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in U937 cell lysate.

Western Blot Analysis: 0.2 µg/ml of this antibody detected UPAR-Associated Protein on 10 µg of U937 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Global Trade Item Number
Numero di catalogo GTIN
MAB2613 04053252611025