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MABC147 Anti-TRAIL/CD253 Antibody, clone 6D12.2

Anti-TRAIL/CD253 Antibody, clone 6D12.2 is an antibody against TRAIL/CD253 for use in flow cytometry & IHC.

Anti-TRAIL/CD253 Antibody, clone 6D12.2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TNFSF10, APO2L, TRAIL UniProt Number: P50591
MABC147
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFC, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC147
DescriptionAnti-TRAIL/CD253 Antibody, clone 6D12.2
Alternate Names
  • Tumor necrosis factor ligand superfamily member 10
  • Apo-2 ligand
  • Apo-2L
  • TNF-related apoptosis-inducing ligand
  • Protein TRAIL
  • CD253
Background InformationApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TRAIL/CD253 Antibody, clone 6D12.2 is an antibody against TRAIL/CD253 for use in flow cytometry & IHC.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry
Application NotesFlow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 human PBMC, which were treated with a proinflammatory stimulus.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAIL/CD253 in human prostate cancer sections. (Note: This antibody detects TRAIL/CD253 in cancer tissues and not in normal tissues.).
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human TRAIL/CD253.
Clone6D12.2
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TNFSF10
  • APO2L
  • TRAIL
Purification MethodProtein G Purified
UniProt Number
Molecular Weight33 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in HeLa cells, which were treated with a proinflammatory stimulus.

Flow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 HeLa cells, which were treated with a proinflammatory stimulus.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABC147 04053252955136