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MABF213 Anti- STING, clone 41 Antibody

This Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.

Anti- STING, clone 41 Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Tmem173, Eris Mita, Mpys, Sting UniProt Number: Q3TBT3
MABF213
100 µL  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, FCRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF213
DescriptionAnti- STING, clone 41 Antibody
Alternate Names
  • Stimulator of interferon genes protein
  • mSTING
  • Endoplasmic reticulum interferon stimulator
  • ERIS
  • Mediator of IRF3 activation
  • MMITA
  • Transmembrane protein 173
  • STING
Background InformationSTING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.
References
Product Information
FormatPurified
PresentationPurified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application NotesFlow Cytometry Analysis: 2 µg of this antibody detected STING in mouse splenocyte cells.
Biological Information
ImmunogenRecombinant protein corresponding to the cytoplasmic domain of mouse STING.
EpitopeCytoplasmic domain
Clone41
Concentration0.5 mg/mL
HostRat
IsotypeIgMκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Tmem173
  • Eris Mita
  • Mpys
  • Sting
UniProt Number
Molecular Weight~42 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~38 kDa and ~48 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected STING in 10 µg of RAW264.7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABF213 04053252983641

Documentation

Anti- STING, clone 41 Antibody MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti- STING, clone 41 Antibody Certificati d'Analisi

TitoloNumero di lotto
Anti-STING, Clone 41 - 4144412 4144412
Anti-STING, clone 41 - Q2442272 Q2442272
Anti-STING, clone 41 - 3173815 3173815
Anti-STING, clone 41 - 3211117 3211117
Anti-STING, clone 41 - 3277584 3277584
Anti-STING, clone 41 - 3542492 3542492
Anti-STING, clone 41 - 3596849 3596849
Anti-STING, clone 41 - 3750070 3750070
Anti-STING, clone 41 - 3795306 3795306
Anti-STING, clone 41 - 3919686 3919686
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