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ABS563 Anti-S1P Lyase Antibody

Anti-S1P Lyase Antibody is an antibody against S1P Lyase for use in Western Blotting, Immunohistochemistry .

Anti-S1P Lyase Antibody : MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: SGPL1, KIAA1252 UniProt Number: O95470
ABS563
100 μg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABS563
DescriptionAnti-S1P Lyase Antibody
Alternate Names
  • Sphingosine-1-phosphate lyase 1
  • S1PL
  • SP-lyase 1
  • SPL 1
  • hSPL
  • Sphingosine-1-phosphate aldolase
  • S1P Lyase
Background InformationSphingosine-1-phosphate lyase 1 (EC 4.1.2.27; UniProt O95470; also known as hSPL, S1P lyase, Sphingosine-1-phosphate aldolase, SPL 1, SP-lyase 1) is a type III single-pass ER membrane protein encoded by the SGPL1 (Also known as S1PL, SPL) gene in human (Gene ID 8879). SP-lyase 1 catalyzes the irreversible retro-aldol cleavage of sphingosine 1-phosphate to 2-hexadecenal and phosphoethanolamine. S1P lyase activity knockout is reported to offer protection in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), by preventing T cell egress from the lymph nodes into central nervous system (CNS). S1P lyase overexpression is also demonstrated to potentiate serum withdrawal-induced apoptosis in HEK293 cultures.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-S1P Lyase Antibody is an antibody against S1P Lyase for use in Western Blotting, Immunohistochemistry .
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected S1P Lyase in human liver and human kidney tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human S1P Lyase.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Chimpanzee, Horse, Porcine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SGPL1
  • KIAA1252
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~70 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected S1P Lyase in 10 µg of human liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABS563 04055977169959