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AB5250-200UL Anti-Potassium Channel TASK1 Antibody

Anti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.

Anti-Potassium Channel TASK1 Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNK3, KT3.1, K2p3.1, TASK-1, TASK1, OAT1, TBAK1 UniProt Number: O14649
AB5250-200UL
200 µL  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RIHC, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB5250-200UL
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Potassium Channel TASK1 Antibody
Alternate Names
  • TWIK-Related Acid Sensitive
  • TASK-1
  • cTBAK
  • Kcnk3
References
Product Information
FormatAffinity Purified
Control
  • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Quality LevelMQ100
Applications
ApplicationAnti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application NotesWestern blot: 1:200 using ECL on rat brain membranes.

Immunohistochemistry on rat brain sections.

Dilutions should be made using a carrier protein such as BSA (1-3%)

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenA purified peptide (TASK) corresponding to amino acid residues 252-269 in the cytoplasmic C-terminus of human TASK1 (Accession O14649).
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThe epitope is specific for TASK1 and is not present in any other known proteins tested so far.

SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues identical) but other species have not been tested.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq]
Gene Symbol
  • KCNK3
  • KT3.1
  • K2p3.1
  • TASK-1
  • TASK1
  • OAT1
  • TBAK1
UniProt Number
UniProt SummaryFUNCTION: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
SIZE: 43518 Da [This is the MW of the unprocessed precursor].
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
MISCELLANEOUS: Inhibited by external acidification. Activated by halothane and isoflurane.
SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
AB5250-200UL 04053252735202

Documentation

Anti-Potassium Channel TASK1 Antibody MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-Potassium Channel TASK1 Antibody Certificati d'Analisi

TitoloNumero di lotto
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 2519182 2519182
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 4027353 4027353
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL - 4166595 4166595
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2557351 2557351
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2575946 2575946
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2606932 2606932
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL -2638913 2638913
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2325767 2325767

Riferimenti bibliografici

Panoramica dei riferimenti bibliograficiCodice d'identificazione nel Pub Med
Expression of TWIK-related acid sensitive K+ channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia
Rau, K. K., et al.
Neuroscience, 141:955-963 (2006)  2005

16725275 16725275

Scheda tecnica

Titolo
RABBIT ANTI-TASK-1 POTASSIUM CHANNEL AFFINITY PURIFIED POLYCLONAL ANTIBODY