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ABE125 Anti-PRMT7 Antibody

Anti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.

Anti-PRMT7 Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: PRMT7 UniProt Number: Q9NVM4
ABE125
200 µL  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE125
DescriptionAnti-PRMT7 Antibody
Alternate Names
  • Protein arginine N-methyltransferase 7
  • Histone-arginine N-methyltransferase PRMT7
  • Myelin basic protein]-arginine N-methyltransferase PRMT7
Background InformationPRMT7, also known as Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7 or Myelin basic protein-arginine N-methyltransferase PRMT7, and encoded by the gene PRMT7/KIAA1933, is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT7 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 (SNRPD1) and SmD3 (SNRPD3). Such methylation is required for the assembly and biogenesis of snRNP core particles. PRMT7 also mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s, and it plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s and thus leading to the recruitment of DNA methyltransferases to those sites. Finally, PRMT7 may also play a role in embryonic stem cell (ESC) pluripotency and is able to methylate histone H2A and myelin basic protein (MBP).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human PRMT7
Epitopeunknown
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody is expected to cross react with all isoforms based upon immunogen design.
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Chimpanzee, Horse, Feline, Bovine, Ferret based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PRMT7
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~75 kDa observed. Uniprot describes four isoforms at 79 kDa (Isoform 1), 62 kDa (Isoform 2), 73 kDa (Isoform 3), and 64 kDa (Isoform 4).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in U2OS nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected PRMT7 in 10 µg of U2OS nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABE125 04053252961113

Prodotti e applicazioni correlate

Related Products

Numero di catalogo Descrizione
07-639 Anti-PRMT7 Antibody