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ABF317 Anti-MICA Antibody

This Anti-MICA Antibody is validated for use in Western Blotting_x000D_ and Immunohistochemistry for the detection of MICA.

Anti-MICA Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: MICA, PERB11.1 UniProt Number: Q29983
ABF317
100 μg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF317
DescriptionAnti-MICA Antibody
Alternate Names
  • MHC class I polypeptide-related sequence A
  • MIC-A
  • MICA
Background InformationThe protein MHC class 1 polypeptide-related sequence A (MIC-A) and encoded by the human gene named MICA is an unusual MHC class one molecule with no known role in antigen presentation but instead acts as a stress-induced self antigen that is recognized by gamma delta T cells and is the ligand for KLRK1/NKG2D cellular receptor. Binding to KLRK1 leads to cell lysis. MICA is a cell membrane associated protein found in the cytoplasm. Additionally, it is expressed in many organ systems and found expressed on many cell types. Expression is induced by many stress responses, including infection, DNA damaging agents, E. coli contact, hCMV and ionizing radiation. MICA is also the antigen for many autoimmune diseases associated with the skin, one organ system where MICA is highly expressed. Psoriasis and Psoriatic arthritis are two such diseases and antibodies to MICA have also been associated with organ transplant difficulties and allograft rejection.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-MICA Antibody is validated for use in Western Blotting_x000D_ and Immunohistochemistry for the detection of MICA.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis (IHC): 10 μg/mL from a representative lot detected MICA in human colon tissue.
Biological Information
ImmunogenMICA antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MICA.
EpitopeNear C-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • MICA
  • PERB11.1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~46 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in A-20 cell lysate.

Western Blotting Analysis (WB): 1 μg/mL of this antibody detected MICA in A-20 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABF317 04055977174656