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05-1108-KC Anti-Insulin, clone MAB1 (1mg) KC

Anti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).

Anti-Insulin, clone MAB1 (1mg) KC: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
05-1108-KC
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Description
Catalogue Number05-1108-KC
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-Insulin, clone MAB1 (1mg) KC
OverviewThis product is intended for use by IVD manufacturers.
Contact customer service for assistance: oem.reagents@emdmillipore.com
Alternate Names
  • Anti-Insulin
Background InformationInsulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
References
Product Information
FormatAffinity Purified
Control
  • Human pancreas tissue.
PresentationThe monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Quality LevelMQ300
Applications
ApplicationAnti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenBiosynthetic human insulin
CloneMAB1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes an epitope including the amino acid B30.
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ILPR
  • IRDN
  • OTTHUMP00000011161
  • OTTHUMP00000011162
  • OTTHUMP00000196038
  • insulin
  • proinsulin
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular WeightApprox. 12 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at 2-8°C and use within 1 year from date of receipt.
Packaging Information
Material SizeBulk packaging. Please inquire.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
05-1108-KC 04053252519895