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MABN543 Anti-Gs protein Antibody, alpha subunit, clone N192/12

Anti-Gs protein Antibody, alpha subunit, clone N192/12 is a highly specific mouse monoclonal antibody & that targets Gsα & has been tested in western blotting.

Anti-Gs protein Antibody, alpha subunit, clone N192/12: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: GNAS, GNAS1 UniProt Number: P04896
MABN543
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN543
DescriptionAnti-Gs protein Antibody, alpha subunit, clone N192/12
Alternate Names
  • Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  • Adenylate cyclase-stimulating G alpha protein
Background InformationThe heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) mediate signaling from a large number of G-protein coupled receptors (GPCR) to a variety of intracellular effectors. G-proteins are composed of a 36-52 kDa α-subunit, a 35-36 kDa β-subunit, and an 8-10 kDa γ-subunit. They are classified based on the nature of their α-subunit. Gs is ubiquitously expressed and couples receptors to adenylyl cyclase and promotes intracellular cAMP generation. Mutations in Gs-α can lead to constitutive activation of receptors leading to development of endocrine tumors, fibrous dysplasia of bone, and McCune-Albright syndrome. In brain tissue Gs-α activates adenyl cyclase in direct response to stimulation of several neurotransmitter receptors and facilitates depolarization-induced neurotransmitter release for synaptic transmission. Also, it is shown that Gs-stimulated adenylyl cyclase activity is significantly reduced in the Alzheimer's disease brain tissue.
References
Product Information
FormatPurified
Control
  • Rat brain membrane tissue lysate
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Gs protein Antibody, alpha subunit, clone N192/12 is a highly specific mouse monoclonal antibody & that targets Gsα & has been tested in western blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected GS protein, alpha subunit in 10 µg of SH-SY5Y cell lysate.
Biological Information
ImmunogenRecombinant protein corresponding to bovine GS protein, alpha subunit.
CloneN192/12
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
  • Rat
Species Reactivity NoteDemonstrated to react with Human and Rat. Predicted to react with Bovine based on immunogen design. Other homologies: Mouse (99% sequence homology).
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GNAS
  • GNAS1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~45 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat brain membrane tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GS protein, alpha subunit in 10 µg of rat brain membrane tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABN543 04053252888618

Documentation

Anti-Gs protein Antibody, alpha subunit, clone N192/12 MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-Gs protein Antibody, alpha subunit, clone N192/12 Certificati d'Analisi

TitoloNumero di lotto
Anti-Gs protein, alpha subunit, clone -2807771 2807771
Anti-Gs protein, alpha subunit, clone N192/12 - Q2166805 Q2166805
Anti-Gs protein, alpha subunit, clone N192/12 - 3243454 3243454
Anti-Gs protein, alpha subunit, clone N192/12 - 3385853 3385853
Anti-Gs protein, alpha subunit, clone N192/12 - 3497289 3497289
Anti-Gs protein, alpha subunit, clone N192/12 - 3602274 3602274
Anti-Gs protein, alpha subunit, clone N192/12 - 3738499 3738499
Anti-Gs protein, alpha subunit, clone N192/12 - 3821796 3821796
Anti-Gs protein, alpha subunit, clone N192/12 - 4000391 4000391
Anti-Gs protein, alpha subunit, clone N192/12 - 4112546 4112546
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