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AB1768-I Anti-GluR2 Antibody

This GluR2 antibody is validated for use in WB & IHC for the detection of the GluR2 protein.

Anti-GluR2 Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience Gene Symbol: Gria2, Glur2 UniProt Number: P19491
AB1768-I
25 µg  
Purchase on Sigma-Aldrich

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Panoramica

Replacement Information
Replacement InformationAB1768-I is a recommended replacement for AB1768-25UG

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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB1768-I
ReplacesAB1768-25UG
DescriptionAnti-GluR2 Antibody
Alternate Names
  • Glutamate receptor 2
  • GluR-2
  • AMPA-selective glutamate receptor 2
  • GluR-B
  • GluR-K2
  • Glutamate receptor ionotropic
  • AMPA 2
  • GluA2
Background InformationGlutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.
Product Information
FormatAffinity Purified
Control
  • Mouse brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis GluR2 antibody is validated for use in WB & IHC for the detection of the GluR2 protein.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:4,000 dilution from a representative lot detected GluR2 in normal human and rat brain tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat GluR2.
EpitopeCytoplasmic domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the cytoplasmic domain of Glutamate Receptor 2.
Species Reactivity
  • Mouse
  • Rat
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Gria2
  • Glur2
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~108 kDa observed. Three isoforms at 99 kDa, 99 kDa, and 100 kDa are known to exist due to alternative splicing.
There is no known homology to mouse and rat GluR1, GluR3 and GluR4. There was no homology detected to GluR1 and GluR3 in human, but there is 67% sequence homology to GluR4. An uncharacterized band may be observed at ~75 kDa in some cell lysates.
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected GluR2 in 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 µg
Global Trade Item Number
Numero di catalogo GTIN
AB1768-I 04053252859267