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MABC288 Anti-Folliculin (FLCN), Antibody clone 8D9.2

This Anti-Folliculin (FLCN), Antibody clone 8D9.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of Folliculin (FLCN).

Anti-Folliculin (FLCN), Antibody clone 8D9.2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FLCN, BHD UniProt Number: Q8NFG4
MABC288
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC288
DescriptionAnti-Folliculin (FLCN), Antibody clone 8D9.2
Alternate Names
  • Folliculin
  • BHD skin lesion fibrofolliculoma protein
  • Birt-Hogg-Dube syndrome protein
  • Folliculin (FLCN)
Background InformationFolliculin (FLCN) is a protein with many possible roles. Folliculin may play a role in the pathogenesis of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). But, Folliculin (FLCN) may be a tumor suppressor, however it is also involved in the generation of colorectal tumorigenesis and renal cell carcinoma, and finally Folliculin (FLCN) might be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutations of Folliculin (FLCN) give rise to Birt-Hogg-Dube syndrome, a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax disorders. Folliculin (FLCN) is widely expressed and localized in both the cytoplasm and nucleus depending upon the conditions in both the fetus and the adult.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Folliculin (FLCN), Antibody clone 8D9.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of Folliculin (FLCN).
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Folliculin (FLCN) in HeLa cells.
Alexa Fluor® is a registered trademark of Life Technologies®.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human Folliculin (FLCN).
Clone8D9.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgMκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FLCN
  • BHD
UniProt Number
Molecular Weight~65 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Folliculin (FLCN) in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABC288 04053252983580