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04-1542 Anti-ETS1 DBD Antibody, clone 1ET 7F2

Use Anti-ETS1 DBD Antibody, clone 1ET 7F2 (Mouse Monoclonal Antibody) validated in WB to detect ETS1 DBD also known as Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, ets protein.

Anti-ETS1 DBD Antibody, clone 1ET 7F2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: ETS1, ETS-1, p54, ETS-1 protein: ETS 1: ETS1, EWSR 2, EWSR2 UniProt Number: P14921
04-1542
100 µL  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBMAscitesMonoclonal Antibody
Description
Catalogue Number04-1542
DescriptionAnti-ETS1 DBD Antibody, clone 1ET 7F2
Alternate Names
  • Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
  • ets protein
  • v-ets avian erythroblastosis virus E2 oncogene homolog 1
  • v-ets avian erythroblastosis virus E26 oncogene homolog 1
  • v-ets erythroblastosis virus E26 oncogene homolog 1
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
  • -ETS-1 protein, ETS 1, ETS1, EWSR 2, EWSR2
Background InformationETS1 belongs to a family of transcription factors that regulates expression of several genes participating in extracellular matrix remodeling. Members of the ETS family regulate a variety of genes involved in stem cell development, cell senescence, and tumorigenesis. ETS1 is typically absent in healthy gastric epithelium, but expressed in many gastric carcinomas and oral squamus cell carcinomas.
This family of transcription factors contains 2 main domains; a transactivation domain (TA), and a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes. This DNA-Binding-Domain is highly conserved among ETS family members.
References
Product Information
FormatAscites
Control
  • HL60 cell lysate
PresentationUnpurified mouse monoclonal IgG1κ in preservative-free ascites.
Quality LevelMQ100
Applications
ApplicationUse Anti-ETS1 DBD Antibody, clone 1ET 7F2 (Mouse Monoclonal Antibody) validated in WB to detect ETS1 DBD also known as Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, ets protein.
Key Applications
  • Western Blotting
Biological Information
ImmunogenLinear peptide corresponding to human ETS1 DBD.
EpitopeUnknown
Cloneclone 1ET 7F2
HostMouse
SpecificityThis antibody recognizes ETS1.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM].
Gene Symbol
  • ETS1
  • ETS-1
  • p54
  • ETS-1 protein: ETS 1: ETS1
  • EWSR 2
  • EWSR2
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Transcription factor.

SIZE: 441 amino acids; 50408 Da

SUBUNIT: Binds to DAXX. Interacts with UBE2I.

SUBCELLULAR LOCATION: Nucleus.

PTM: Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity (By similarity). & Ubiquitinated; which induces proteasomal degradation (By similarity).

DISEASE: ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.

SIMILARITY: Belongs to the ETS family. & Contains 1 ETS DNA-binding domain. & Contains 1 PNT (pointed) domain.
Molecular Weight~ 50 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HL60 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected ETS1 DBD on 10 µg of HL60 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
04-1542 04053252590443

Documentation

Anti-ETS1 DBD Antibody, clone 1ET 7F2 MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-ETS1 DBD Antibody, clone 1ET 7F2 Certificati d'Analisi

TitoloNumero di lotto
Anti-ETS1 DBD, clone 1ET 7F2 - 2459493 2459493
Anti-ETS1 DBD, clone 1ET 7F2 - 2038643 2038643
Anti-ETS1 DBD, clone 1ET 7F2 - 3323149 3323149
Anti-ETS1 DBD, clone 1ET 7F2 - NG1806864 NG1806864
Anti-ETS1 DBD, clone 1ET 7F2 - NG1947026 NG1947026
Anti-ETS1 DBD, clone 1ET 7F2 - NRG1718894 NRG1718894
Anti-ETS1 DBD, clone 1ET 7F2 Monoclonal Antibody 2975842
Anti-ETS1 DBD, clone 1ET 7F2 Monoclonal Antibody 2905379