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ABF212 Anti-CIITA Antibody

Detect MHC class II transactivator using this rabbit polyclonal antibody, Anti-CIITA Antibody validated for use in western blotting & IHC.

Anti-CIITA Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: CIITA UniProt Number: P33076
ABF212
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF212
DescriptionAnti-CIITA Antibody
Alternate Names
  • MHC class II transactivator
  • MHC2TA
  • C2TA
  • NLRA
  • CIITAIV
Background InformationCIITA, also known as MHC class II transactivator (MHC2TA), is located in the nucleus and is an essential factor for transcriptional activity of the HLA class II promoter. CIITA is suggested to be a positive regulator of class II major histocompatibility complex gene transcription and is referred to as the "master control factor" for the expression of these genes. Additionally, CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. CIITA binds with GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind with DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Furthermore, it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. CIITA has been shown to interact with ZXDA and ZXDC. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
References
Product Information
FormatAffinity Purified
Control
  • Mouse brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect MHC class II transactivator using this rabbit polyclonal antibody, Anti-CIITA Antibody validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: 10 µg/mL from a representative lot detected CIITA in human brain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human CIITA.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Mouse
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • CIITA
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~122 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected CIITA in 15 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABF212 04053252912290