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MABF412 Anti-CD4 Antibody (mouse), FITC, clone GK1.5

This Rat Monoclonal Antibody Anti-CD4 (mouse), FITC, clone GK1.5, Cat. No. MABF412 is validated for use in IP, IHC, FC for the detection of CD4.

Anti-CD4 Antibody (mouse), FITC, clone GK1.5: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Gene Symbol: Cd44, Ly-24 UniProt Number: P15379
MABF412
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
MIP, IHC, FCRFITCMonoclonal Antibody
Description
Catalogue NumberMABF412
DescriptionAnti-CD4 Antibody (mouse), FITC, clone GK1.5
Alternate Names
  • CD44 antigen
  • Extracellular matrix receptor III
  • ECMR-III
  • GP90 lymphocyte homing/adhesion receptor
  • HUTCH-I
  • Hermes antigen
  • Hyaluronate receptor
  • Lymphocyte antigen 24
  • Ly-24
  • Phagocytic glycoprotein 1
  • PGP-1
  • Phagocytic glycoprotein I
  • PGP-I
  • CD44
Background InformationThe GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
References
Product Information
FormatFITC
PresentationPurified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Rat Monoclonal Antibody Anti-CD4 (mouse), FITC, clone GK1.5, Cat. No. MABF412 is validated for use in IP, IHC, FC for the detection of CD4.
Key Applications
  • Immunoprecipitation
  • Immunohistochemistry
  • Flow Cytometry
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
CloneGK1.5
Concentration0.5 mg/mL
HostRat
IsotypeIgG2bκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Cd44
  • Ly-24
Purification MethodSize Exclusion Chromatography
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABF412 04053252960048

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Categorie

Life Science Research > Antibodies and Assays > Primary Antibodies