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MABN1583 Anti-CALML5 Antibody, clone 3F6.1

Anti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-CALML5 Antibody, clone 3F6.1 : MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: CALML5, CLSP UniProt Number: Q9NZT1
MABN1583
100 μg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN1583
DescriptionAnti-CALML5 Antibody, clone 3F6.1
Alternate Names
  • Calmodulin-like protein 5
  • Calmodulin-like skin protein
Background InformationCalmodulin-like protein 5 (UniProt Q9NZT1; also known as Calmodulin-like skin protein) is encoded by the CALML5 (also known as CLSP) gene (Gene ID 51806) in human. Epidermal differentiation and barrier function depend on many calcium-regulated proteins and enzymes. CALML5/CLSP is expressed in the stratum granulosum and lower layers of the stratum corneum of the skin, where it modulates the function of calcium-dependent proteins, such as transglutaminase 3. CALML5/CLSP level is upregulated in granular and spinal keratinocytes during the later stages of wound healing in human epidermis and eventually returns to basal level once the wound is closed and barrier function has been restored. In the hyperproliferative skin disorders psoriasis and atopic dermatitis (AD), the permeability barrier is disturbed, causing an increased CLSP built-up as a result of decresed CLSP degradation due to an altered calcium gradient.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CALML5 in human tonsil and skin tissue sections.
Biological Information
ImmunogenGST-tagged recombinant human CALML5 lacking the first EF-hand motif.
EpitopeOutside the first EF-hand motif.
Clone3F6.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 3F6.1 recognizes an epitope outside the first EF-hand motif.
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CALML5
  • CLSP
Purification MethodProtein G Purified
UniProt Number
Molecular Weight15.89 kDa calculated. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting of human CALML5 GST fusion protein.

Western Blotting Analysis: 0.05 µg/mL of this antibody detected 0.05 µg of human CALML5 GST fusion protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABN1583 04055977335309