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ABN486 Anti-Anosmin Antibody

Anti-Anosmin Antibody is a highly specific rabbit polyclonal antibody, that targets Anosmin & has been tested in western blotting & ICC.

Anti-Anosmin Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: KAL1 UniProt Number: P23352
ABN486
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN486
DescriptionAnti-Anosmin Antibody
Alternate Names
  • Anosmin
  • Anosmin-1
  • Adhesion molecule-like X-linked
  • Kallmann syndrome protein
  • KALIG-1
  • KAL1
  • HHA
  • KMS
  • ADMLX
  • KAL
  • KALIG1
Background InformationAnosmin is a large (100 kDa) secreted peripheral membrane heparin binding glycoprotein that plays a role in neurodevelopment. Anosmin influences the patterning of the mitral and tufted cell collaterals and stimulates axon elongation and branching in the olfactory system, and it seems to have a critical role in the spatiotemporal arrangement in cranial neural cell formation. The protein interacts with FGFR1 and promotes FGF receptor mediated gene expression but it also inhibits BMP5 and WNT3A signaling activities. It is thought through this orchestration that Anosmin controls the epithelial–mesenchymal transition and the mesenchymal–epithelial transition during neural crest cell development. Mutations in the Anosmin gene, KAL1, are the cause of hypogonadotropic hypogonadism 1. A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. EMD-Millipore’s anti-Anosmin rabbit polyclonal antibody has been tested in western blot against human MCF7 cells and immunocytochemistry against MCF7 cells in culture.
References
Product Information
FormatAffinity Purified
Control
  • MCF7cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Anosmin Antibody is a highly specific rabbit polyclonal antibody, that targets Anosmin & has been tested in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Anosmin in human cerebellum, rat cerebellum, and human thalamus tissues.

Immunocytochemistry Analysis: 5 µg/mL from a representative lot detected Anosmin in MCF7 cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Anosmin.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • KAL1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~70 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in MCF7 cell lysate.

Western Blotting Analysis: 1µg/mL of this antibody detected Anosmin in 15 µg of MCF7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
ABN486 04053252923500