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MABE903 Anti-ACD Antibody, clone 1G10.3

Anti-ACD Antibody, clone 1G10.3 is an antibody against ACD for use in Western Blotting and Immunocytochemistry.

Anti-ACD Antibody, clone 1G10.3: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: ACD, PIP1, PTOP, TINT1, TPP1 UniProt Number: Q96AP0
MABE903
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMAffinity PurifiedMonoclonal Antibody
Description
Catalogue NumberMABE903
DescriptionAnti-ACD Antibody, clone 1G10.3
Alternate Names
  • ACD
  • Adrenocortical dysplasia protein homolog
  • POT1 and TIN2-interacting protein
Background InformationAdrenocortical dysplasia protein homolog (also known as POT1 and TIN2 organizing protein or TIN2-interacting protein) is a nuclear protein encoded by the ACD gene in human (also known as PIP1, PTOP, TINT1, TPP1). It a component of the shelterin complex (telosome) and is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways. The ACD-POT1 heterodimer is reported to enhance telomere elongation by increasing telomerase processivity (PMID 17237768).
References
Product Information
FormatAffinity Purified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-ACD Antibody, clone 1G10.3 is an antibody against ACD for use in Western Blotting and Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 4.0 µg/mL from a representative lot detected ACD in HeLa, A431, and NIH/3T3 cells.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human ACD.
Clone1G10.3
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ACD
  • PIP1
  • PTOP
  • TINT1
  • TPP1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~60 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected ACD in 10 µg of HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABE903 04055977159301