114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
More>> A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. Less<<Adapalene - CAS 106685-40-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Sinonimi: CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
Prodotti consigliati
Panoramica
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Tabella delle specifiche principali
| CAS # | Empirical Formula |
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| 106685-40-9 | C₂₈H₂₈O₃ |
Products
| Numero di catalogo | Confezionamento | Qtà/conf | |
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| 114825-25MG | 25 mg |
| Description | |
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| Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
| Catalogue Number | 114825 |
| Brand Family | Calbiochem® |
| Synonyms | CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271 |
| Product Information | |
|---|---|
| CAS number | 106685-40-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈O₃ |
| Chemical formula | C₂₈H₂₈O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Numero di catalogo | GTIN |
| 114825-25MG | 04055977208122 |
Documentation
Adapalene - CAS 106685-40-9 - Calbiochem MSDS
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Adapalene - CAS 106685-40-9 - Calbiochem Certificati d'Analisi
| Titolo | Numero di lotto |
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| 114825 |
Riferimenti bibliografici
| Panoramica delle referenze |
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| Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
Brochure
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| Analisi dell'acqua e degli alimenti |
| Undisputed Accuracy for Your Quantitative Results |
| Water, Food & Environmental Analytics - Test Kits, Instruments and Accessories (Italian) |
Informazioni tecniche
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| Programming data for Spectrophotometer and Spectroquant Test Kits |