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190080 AY 9944 - CAS 366-93-8 - Calbiochem

A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.

AY 9944 - CAS 366-93-8 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV

Primary Target: 7-dehydrocholesterol reductase (δ7-sterol reductase)
190080
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
366-93-8C₂₂H₂₈Cl₂N₂ • 2HCl

Products

Numero di catalogoConfezionamento Qtà/conf
190080-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
Catalogue Number190080
Brand Family Calbiochem®
Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
References
ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
Product Information
CAS number366-93-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₈Cl₂N₂ • 2HCl
Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target7-dehydrocholesterol reductase (δ7-sterol reductase)
Primary Target IC<sub>50</sub>13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGU7025000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
190080-5MG 04055977221336

Documentation

AY 9944 - CAS 366-93-8 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

AY 9944 - CAS 366-93-8 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
190080

Riferimenti bibliografici

Panoramica delle referenze
Gofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-October-2007 JSW
Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
DescriptionA cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number366-93-8
RTECSGU7025000
Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (20 mg/ml) or DMSO (20 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.