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454180 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene

Primary Target: Inhibits cell proliferation and angiogenesis
454180
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
362-07-2C₁₉H₂₆O₃

Products

Numero di catalogoConfezionamento Qtà/conf
454180-10MG Fusto in alluminio 10 mg
454180-50MG Fusto in alluminio 50 mg
Description
OverviewA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Catalogue Number454180
Brand Family Calbiochem®
Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
References
ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
Forsis, T., et al. 1994. Nature 368, 237.
Product Information
CAS number362-07-2
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₉H₂₆O₃
Chemical formulaC₁₉H₂₆O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits cell proliferation and angiogenesis
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-36/37/38

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
454180-10MG 04055977204728
454180-50MG 04055977204735

Documentation

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
454180

Riferimenti bibliografici

Panoramica delle referenze
Aizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
Forsis, T., et al. 1994. Nature 368, 237.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
DescriptionA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.
FormWhite crystalline solid
CAS number362-07-2
Chemical formulaC₁₉H₂₆O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO or Ethanol
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Toxicity Toxic
ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
Forsis, T., et al. 1994. Nature 368, 237.