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676777 (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem

A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.

(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: L-Type Calcium Channel Blocker V

Primary Target: L-type Ca2+ channels
676777
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
152-11-4C₂₇H₃₈N₂O₄ · HCl

Products

Numero di catalogoConfezionamento Qtà/conf
676777-100MG Fusto in alluminio 100 mg
Description
OverviewA papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
Catalogue Number676777
Brand Family Calbiochem®
SynonymsL-Type Calcium Channel Blocker V
References
ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
Product Information
CAS number152-11-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₇H₃₈N₂O₄ · HCl
Chemical formulaC₂₇H₃₈N₂O₄ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetL-type Ca2+ channels
Purity≥99% by titration (with perchloric acid)
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYV8320000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
676777-100MG 07790788052331

Documentation

(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
676777

Riferimenti bibliografici

Panoramica delle referenze
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
Janis, R., et al. 1987. Adv. Drug Res. 16, 309.

Brochure

Titolo
Caspases and other Apoptosis Related Tools Brochure

Citazioni

Titolo
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-May-2008 RFH
    SynonymsL-Type Calcium Channel Blocker V
    DescriptionA derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
    FormWhite solid
    CAS number152-11-4
    RTECSYV8320000
    Chemical formulaC₂₇H₃₈N₂O₄ · HCl
    Structure formulaStructure formula
    Purity≥99% by titration (with perchloric acid)
    SolubilityH₂O (70 mg/ml), Ethanol, or Methanol (50 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
    Toxicity Toxic
    Merck USA index14, 9950
    ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
    Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
    Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
    Citation
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•