Your Neuroscience Antibody Search Ends Here.
Neuroscience is a heterogeneous field, requiring integrated analysis of multiple cell types, tissues and organs, using diverse techniques. The next advance in neuroscience will likely rely on antibodies and immunodetection, given that researchers tend to build upon traditional technologies rather than abandon them.
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Antibody-based biomarker detection reagents are now available for numerous cell and tissue types, disease states, and for measuring responses to targeted therapies. These extremely specific, robust immunoprobes are now used with high-tech fluorescent secondary antibodies and powerful microscopes, keeping alive the classic technique of immunocytochemistry in neuroscience research. Western blotting, another established immunodetection technique for cell and tissue lysates, has been vastly improved by membrane (and probe) technology.
Understanding our complex brain requires a comprehensive portfolio of neuroscience antibodies, kits, and immunodetection reagents. By integrating the antibody expertise and resources of Calbiochem®, Chemicon®, Upstate®, and Linco®, Merck is now the leading provider of neuroscience antibodies for the central and peripheral nervous systems. Our vast neuroscience portfolio includes pathway-, cell type-, and state-specific antibodies and neurological disease assays and markers.
Merck is committed to creating and supplying the most trusted and validated collection of neuroscience antibodies and assays for studying structure and function, development, systems, and degeneration and disorders of the nervous system. Drive your neuroscience research forward.
Pick Your Topic, Find Your Antibody
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Structure & Function
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Neural stem cells can differentiate into three major cell types in the central nervous system: neurons, astrocytes, or oligodendrocytes. These building blocks of the brain must expand, connect, and mature to perform their sophisticated functions.
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The study of the differentiated nervous system includes many disparate fields, converging on key research areas such as Synapses, Neurons, and Glia; Transmitters, Receptors, Ion Channels & Transporters; Neural Signaling; and Neuronal Adhesion. Merck is strongly dedicated to supporting research in these areas. Explore our robust portfolio of validated antibodies for synaptic proteins, neuronal and glial markers, transmitters, receptors, ion channels, transporters, as well as those for signaling and adhesion.
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Development
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Nervous system complexity requires an intricate, precise developmental plan. Patterns of cell differentiation, signaling, migration, neurite outgrowth, and synapse formation occur across the embryo with unparalleled choreography.
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The broad array of immunodetection techniques now available and emerging technologies in genetics and epigenetics are helping to reveal the processes underlying brain development and disease. Consider our antibodies for investigating neurite outgrowth and neuronal development, from stem cells to differentiation.
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Systems
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The systems of the nervous system are complex, yet brilliant. Sensing the environment and controlling body systems define an organism’s behavior and are intricately tied to neural processes. Identification of key neuro-hormones and receptors has demonstrated a larger role for the CNS in adjusting parameters, such as energy expenditure, growth, and reproduction.
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Sensory system dysfunction is often the most keenly felt result of neural damage or developmental disorder. Sensory system research focuses on peripheral and central processing mechanisms in the visual, auditory, olfactory, gustatory, and pain systems. Merck’s comprehensive set of antibodies target key molecules involved in metabolic control, hormonal regulation, sensory systems and the circadian rhythm. Explore the mechanisms using specific antibodies to molecules involved in various systems including metabolic, pain, vision, circadian, and more.
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Disease
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Diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and prion diseases, as well as neurochemical degenerative factors like oxidative stress, free radical damage, and inflammation all follow complex cellular pathways.
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Merck offers a broad range of antibodies and detection kits for tracking many steps in neuronal degeneration, including those that measure mitochondrial health, apoptosis, and downstream inflammation.
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Other Neuroscience Research Areas:
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Neuroscience is driven by difficult and insightful questions. Merck has technologies that answer. Since incorporating the expertise of Chemicon®, Upstate®, and Calbiochem®, Merck has been committed to developing comprehensive neuroscience research solutions.
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We are dedicated to providing quality, cutting edge tools to the neuroscience community and look forward to a mutually beneficial collaboration for decades to come. Our growing portfolio of conformation-specific antibodies gives you a new level of confidence in protein detection – specificity for conformations that are important for your research. Optogenetics is another very interesting technique that allows researchers to modulate the activity of target neurons using specific wavelengths of light. This is accomplished by coupling genetic expression of light-sensitive channel proteins within targeted cells to precision light exposure and measurement.
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