681665 Sigma-AldrichWnt Agonist - CAS 853220-52-7 - Calbiochem
Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
More>> Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM). Less<<Synonymes: 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
Produits recommandés
Aperçu
Replacement Information |
---|
Tableau de caractéristiques principal
CAS # | Empirical Formula |
---|---|
853220-52-7 | C₁₉H₁₈N₄O₃ |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
---|---|---|---|---|---|---|
681665-5MG |
|
Ampoule plast. | 5 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664). |
Catalogue Number | 681665 |
Brand Family | Calbiochem® |
Synonyms | 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I |
References | |
---|---|
References | Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987. |
Product Information | |
---|---|
CAS number | 853220-52-7 |
ATP Competitive | N |
Form | Yellowish sticky solid |
Hill Formula | C₁₉H₁₈N₄O₃ |
Chemical formula | C₁₉H₁₈N₄O₃ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
---|---|
Application | Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM). |
Physicochemical Information | |
---|---|
Cell permeable | Y |
Dimensions |
---|
Materials Information |
---|
Toxicological Information |
---|
Safety Information according to GHS |
---|
Safety Information |
---|
Product Usage Statements |
---|
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Transport Information |
---|
Supplemental Information |
---|
Specifications |
---|
Global Trade Item Number | |
---|---|
Référence | GTIN |
681665-5MG | 04055977260236 |
Documentation
Wnt Agonist - CAS 853220-52-7 - Calbiochem FDS
Titre |
---|
Wnt Agonist - CAS 853220-52-7 - Calbiochem Certificats d'analyse
Titre | Numéro de lot |
---|---|
681665 |
Références bibliographiques
Aperçu de la référence bibliographique |
---|
Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987. |
Brochure
Titre |
---|
Stem Cell Resource Brochure GBP |