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534359 TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem

Highly efficacious TRPM3 Agonist that opens both the central Ca2+-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice.

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Synonymes: ±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216

Primary Target: TRPM3
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534359
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Tableau de caractéristiques principal

CAS #Empirical Formula
1031496-06-6C₂₁H₂₁N₃O₂

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      Description
      OverviewA cell-permeable isoxazolyl-phenylacetamide based compound that acts as a potent, reversible, temperature-dependent and selective activator of both human and murine TRPM3 currents (EC50 = 770 nM for elevating [Ca2+]i levels in HEK293-TRPM3 cells; maximal activation within ~100 s) in a dose-dependent & membrane-delimited manner. Poorly activates human TRPM1, TRPM2, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 and TRPV1. At higher concentrations, blocks hTRPM2, hTRPM5 & hTRPM8 (by 17%, 34% & 61%, respectively, at 10 µM). Elicits the opening of both the central calcium-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice (2.5 nmol, intradermal), induces pain, and stimulates the release of CGRP from skin nerve terminals and insulin from pancreatic islets. Shown to display greater efficacy than the canonical TRPM3 agonist, pregnenolone sulfate.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number534359
      Brand Family Calbiochem®
      Synonyms±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216
      DescriptionTRPM3 Agonist, CIM0216
      References
      ReferencesHeld, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.
      Product Information
      CAS number1031496-06-6
      FormWhite to light yellow solid
      Hill FormulaC₂₁H₂₁N₃O₂
      Chemical formulaC₂₁H₂₁N₃O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTRPM3
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.34359.0001 04054839059247

      Documentation

      TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      534359

      Références bibliographiques

      Aperçu de la référence bibliographique
      Held, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-October-2024 JSW
      Synonyms±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216
      DescriptionA cell-permeable isoxazolyl-phenylacetamide based compound that acts as a potent, reversible, temperature-dependent and selective activator of both human and murine TRPM3 currents (EC50 = 770 nM for elevating [Ca2+]i levels in HEK293-TRPM3 cells; maximal activation within ~100 s) in a dose-dependent & membrane-delimited manner. Poorly activates human TRPM1, TRPM2, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 and TRPV1. At higher concentrations, blocks hTRPM2, hTRPM5 & hTRPM8 (by 17%, 34% & 61%, respectively, at 10 µM). Elicits the opening of both the central calcium-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice (2.5 nmol, intradermal), induces pain, and stimulates the release of CGRP from skin nerve terminals and insulin from pancreatic islets. Shown to display greater efficacy than the canonical TRPM3 agonist, pregnenolone sulfate.
      FormWhite to light yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1031496-06-6
      Chemical formulaC₂₁H₂₁N₃O₂
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHeld, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.