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569397 Staurosporine, Streptomyces sp.

Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC₅₀ = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).

Staurosporine, Streptomyces sp. : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MLCK Inhibitor I, PKA Inhibitor II

Primary Target: PKA
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569397
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Aperçu

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Tableau de caractéristiques principal

CAS #Empirical Formula
62996-74-1C₂₈H₂₆N₄O₃

Prix & Disponibilité

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569397-100UG
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      569397-1MG
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          		 Ampoule plast. 1 mg
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          569397-250UG
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              		 Ampoule plast. 250 μg
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              Description
              OverviewA potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A (IC50 = 7 nM), CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase C (IC50 = 700 pM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint. A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569396) in DMSO is also available.
              Catalogue Number569397
              Brand Family Calbiochem®
              SynonymsMLCK Inhibitor I, PKA Inhibitor II
              References
              ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
              Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
              Bruno, S., et al. 1992. Cancer Res. 52, 470.
              Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
              Vitale, M.L., et al. 1992. Neuroscience 51, 463.
              Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
              Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
              Product Information
              CAS number62996-74-1
              ATP CompetitiveY
              FormWhite to pale yellow solid
              Hill FormulaC₂₈H₂₆N₄O₃
              Chemical formulaC₂₈H₂₆N₄O₃
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetPKA
              Primary Target IC<sub>50</sub>7 nM, 20 nM, 1.3 nM, 700 pM, and 8.5 nM against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Référence GTIN
              569397-100UG 07790788057855
              569397-1MG 04055977190465
              569397-250UG 04055977190496

              Documentation

              Staurosporine, Streptomyces sp. FDS

              Titre

              Fiche de données de sécurité des matériaux (FDS) 

              Staurosporine, Streptomyces sp. Certificats d'analyse

              TitreNuméro de lot
              569397

              Références bibliographiques

              Aperçu de la référence bibliographique
              Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
              Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
              Bruno, S., et al. 1992. Cancer Res. 52, 470.
              Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
              Vitale, M.L., et al. 1992. Neuroscience 51, 463.
              Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
              Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

              Brochure

              Titre
              Caspases and other Apoptosis Related Tools Brochure
              Protein Kinase Assay and Detection Kits Brochure
              Tools and Tips for Analyzing Apoptosis

              Citations

              Titre
            • Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958.
            • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
            • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
              		•
              Fiche technique

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-July-2014 JSW
              SynonymsMLCK Inhibitor I, PKA Inhibitor II
              DescriptionA potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
              FormWhite to pale yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number62996-74-1
              Chemical formulaC₂₈H₂₆N₄O₃
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (5 mg/ml). Further dilute with aqueous buffers just prior to use.
              Storage Protect from light
              +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
              Toxicity Standard Handling
              ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
              Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
              Bruno, S., et al. 1992. Cancer Res. 52, 470.
              Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
              Vitale, M.L., et al. 1992. Neuroscience 51, 463.
              Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
              Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
              Citation
            • Joao B. Oliveira, et al. (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Procedings of the National Academy of Science 104, 8953-8958.
            • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
            • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
              		•

              Produits & Applications associés

              Catégories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors